Australian Open holder Djokovic will make his ATP Cup debut for Serbia against South Africa in Brisbane on Saturday while Nadal will lead Spain into action against Georgia in Perth on the same day.
Jennifer Brady spent two weeks in hard quarantine gathering mental strength for her tilt at a maiden Grand Slam title and will hope there is plenty in reserve when she takes on Naomi Osaka in Saturday's Australian Open final.
The hard court, outdoor competition in Lexington, Kentucky, marked the WTA's first tournament in the United States since the coronavirus outbreak forced almost all sport into a long break earlier this year.
Pole says she feels much better prepared to handle the pressure of her latest career milestone.
New York Governor Andrew Cuomo said the USTA would take "extraordinary precautions" to protect players, including robust testing, additional cleaning, extra locker room space and dedicated accommodation.
A round-up of all tennis action on Saturday.
Halep's near-flawless display at the All England Club marked a spectacular return to form after her world ranking dropped from first to seventh between mid-January and July.
The professional tennis circuit, which requires players to jet around the world, was forced into shutdown in early March as countries went into lockdown and closed their borders to contain the spread of the novel coronavirus.
The 23-times Grand Slam champion looked a completely different player from the person who smashed her way into the semi-finals of the doubles with Caroline Wozniacki on Wednesday but managed to do just enough to beat the 86th-ranked McHale.
American Sofia Kenin counter-punched her way back from a set down against Garbine Muguruza to win her first Grand Slam title at the Australian Open with a 4-6, 6-2, 6-2 win in Melbourne on Saturday. The 21-year-old Kenin, seeded 14th at Melbourne Park, converted her second matchpoint against the twice Grand Slam champion, who double faulted on the final point, to end an engrossing contest that lasted more than two hours.
That is Murray's 46th ATP title.
Images from Day 7 at the US Open.
It has been 24 days since Victoria reported a locally acquired COVID-19 infection, while Australia as a whole posted a 13th straight day without a community case on Saturday.
American Jennifer Brady defeated compatriot Coco Gauff 6-2, 6-4 at the Top Seed Open on Saturday, earning a spot in her first WTA final.
Andy Murray took a step closer to a first title in arguably the toughest year of his playing career, grinding out a 3-6, 7-5 ,6-2 win over Ugo Humbert on Saturday to reach the final of the European Open in Antwerp.
IMAGES from Day 2 of the US Open played at Flushing Meadows in New York on Tuesday.
Images from Day 3 of the French Open matches played at Roland Garros on Tuesday
IMAGES from the matches played during the Wimbledon Championships at the All England Lawn Tennis and Croquet Club, at Wimbledon in London on Thursday
Simona Halep finds the prospect of 14 days of quarantine ahead of the Australian Open daunting
World number two Karolina Pliskova beat Croatia's Petra Martic 6-3, 6-2 in the final of the inaugural Zhengzhou Open on Sunday to win the 15th WTA singles title of her career and her first in China.
A six-time champion at Flushing Meadows, Williams was once money in the bank when it came to the US Open
Images from Day 7 of the 2021 French Open at Roland Garros in Paris on Saturday.
IMAGES from Australian Open matches played at Melbourne Park on Friday
Perry said she had been in touch with the local organising team on a daily basis as they prepare to start the tournament on October 19, pending government approval and confirmation that players will be able to travel.
Images from Saturday's action at the Australian Open.
Garbine Muguruza stormed back into the Grand Slam big time with a 7-5, 6-3 win over Russian Anastasia Pavlyuchenkova to reach her first Australian Open semi-final. Fourth seed Simona Halep advanced to her second Australian Open semi-final with a 6-1, 6-1 demolition of Estonia's Anett Kontaveit in just 53 minutes on Rod Laver Arena.
Serena Williams returns to the Arthur Ashe Stadium on Sunday
IMAGES from Day 2 of the Wimbledon Championships from the All England Lawn Tennis and Croquet Club, London, on Tuesday.
Melbourne man McNamara won five singles titles and 19 in doubles and teamed up with compatriot Paul McNamee to win the Australian Open doubles in 1979 and Wimbledon twice in 1980 and 1982.
Images from Day 7 of the 2021 US Open in New York on Sunday.
Marin Cilic and Milos Raonic booked their spots in the Paris Masters second round on Monday, while Roger Federer pulled out of the tournament with next month's ATP Finals on the horizon.
Sania ousted from Qatar Total Open.
PHOTOS from the Wimbledon Championships matches played at the All England Lawn Tennis and Croquet Club, London, on Saturday
Images from Day 3 of the Australian Open in Melbourne on Wednesday
IMAGES from the Australian Open matches played on Friday.
Under the lights on the stadium court, Williams smashed 39 winners to defeat Azarenka 7-5, 6-3 in a rematch of the 2016 final, which the Belarusian won.
Images from the third day at the US Open, the final Grand Slam tournament of the year, in New York, on Wednesday:
Daniil Medvedev and Karen Khachanov crushed second seed Dominic Thiem and third seed Alexander Zverev respectively to set up an all-Russian semi-final at the Rogers Cup in Montreal on Friday.
Novak Djokovic and Rogerer Federer loom over Melbourne Park for the year's opening Grand Slam as favourites for the Australian Open as questions remain as to whether one of Generation Next could finally end their stranglehold.
Images from Day 1 of the Australian Open in Melbourne on Monday.